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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIF22 All Species: 26.36
Human Site: T463 Identified Species: 58
UniProt: Q14807 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14807 NP_015556.1 665 73262 T463 Q G A P L L S T P K R E R M V
Chimpanzee Pan troglodytes XP_510910 679 74714 T463 Q G A P L L S T P K R E R M V
Rhesus Macaque Macaca mulatta XP_001104365 657 72278 T452 Q G A P L L S T P K R E R M V
Dog Lupus familis XP_547058 651 71817 T446 Q G T H G L N T P R R E R M V
Cat Felis silvestris
Mouse Mus musculus Q3V300 660 73171 T458 Q G T P L L N T P K R E R M V
Rat Rattus norvegicus Q5I0E8 657 73037 T455 Q G I P L L N T P K R E R M V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q7ZYL5 650 73149 T450 K E A Q L L S T P K R E R M A
Zebra Danio Brachydanio rerio A8WFU8 634 70574 A434 L N L L K T V A Q S R K E I Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46867 784 88189 R447 K S N E E L E R E R V E N S K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P46873 699 78760 S508 L E K E V K K S K G Y E R E I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LPC6 894 98404 V507 N G E V N G V V T A S E F T R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.1 94.8 90 N.A. 81.3 81 N.A. N.A. N.A. 52.3 50.9 N.A. 29.2 N.A. 28.1 N.A.
Protein Similarity: 100 97.5 96.2 93 N.A. 88.7 88.8 N.A. N.A. N.A. 69.3 66.1 N.A. 46.1 N.A. 45.7 N.A.
P-Site Identity: 100 100 100 66.6 N.A. 86.6 86.6 N.A. N.A. N.A. 73.3 6.6 N.A. 13.3 N.A. 13.3 N.A.
P-Site Similarity: 100 100 100 80 N.A. 93.3 93.3 N.A. N.A. N.A. 80 20 N.A. 26.6 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 37 0 0 0 0 10 0 10 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 19 10 19 10 0 10 0 10 0 0 91 10 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 64 0 0 10 10 0 0 0 10 0 0 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 10 10 % I
% Lys: 19 0 10 0 10 10 10 0 10 55 0 10 0 0 10 % K
% Leu: 19 0 10 10 55 73 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 64 0 % M
% Asn: 10 10 10 0 10 0 28 0 0 0 0 0 10 0 0 % N
% Pro: 0 0 0 46 0 0 0 0 64 0 0 0 0 0 0 % P
% Gln: 55 0 0 10 0 0 0 0 10 0 0 0 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 10 0 19 73 0 73 0 10 % R
% Ser: 0 10 0 0 0 0 37 10 0 10 10 0 0 10 0 % S
% Thr: 0 0 19 0 0 10 0 64 10 0 0 0 0 10 0 % T
% Val: 0 0 0 10 10 0 19 10 0 0 10 0 0 0 55 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _